朱书

实验室主页：http://redbookyale.wixsite.com/zhu-lab-ustc  

主要研究方向：

肠道作为人体最大的粘膜免疫器官，聚集了远超过人体细胞数目的微生物，当前的研究显示这些微生物不仅和人体保持共生关系，为人体正常生理过程比如营养物质的代谢和吸收提供帮助，在特定情况下也会对人类疾病造成负面的影响，比如说促进免疫性疾病（IBD），代谢性疾病（肥胖），神经性疾病（抑郁），甚至肿

瘤。另外大量肠道微生物的存在导致肠道共同进化形成拥有由功能各异的上皮细胞组成的黏膜屏障，以及由全身一半以上的免疫细胞组成的复杂精密的免疫系统。实验室的兴趣在于利用小鼠模型来研究在正常情况下，肠道黏膜屏障如何隔绝微生物，免疫细胞和上皮细胞如何识别微生物，以及肠道T细胞如何介导和调节针对微生物免疫反应。另外由于遗传，感染，饮食等造成的肠道微生态失调和人类疾病紧密相关，实验室对于肠道微生态失调是如何形成，以及失调的微生态是如何影响肠道免疫反应和人类疾病也非常感兴趣。以期通过靶向宿主免疫反应，或者直接靶向微生态，来实现对于人类疾病比如感染，免疫性疾病和肿瘤的干预。实验室将主要利用擅长的多种小鼠模型（KI/KO, reporter,疾病模型,人源化），CRISPR筛选和新一代测序来研究：1）肠道黏膜屏障，先天免疫识别，感染和炎症2）T细胞介导的免疫反应，自身免疫和肿瘤3）疾病状态下肠道微生态谱（细菌和病毒），微生态失调的形成机制以及微生态失调对免疫系统和疾病的影响。

朱书，男，1984年出生，博士，中国科学技术大学生命科学学院教授、博士生导师。 2017年入选微尺度国家研究中心以及中科院分子细胞卓越中心。

朱书教授2006年获中国科学技术大学生物学学士学位，郭沫若奖学金获选者。2012年获中国科学院上海生命科学研究院博士学位，吴瑞奖学金获得者，两获中科院院长奖学金，论文入选中科院百篇优秀博士生论文。同年进入美国耶鲁大学免疫学系，师从美国科学院院士，HHMI，系主任Richard Flavell进行博士后研究，2013年获 Helen Hay Whitney基金会及HHMI联合资助。目前主要以小鼠模型研究肠道免疫系统与微生物的互作对健康和疾病的影响。现已发表学术论文30篇，并以第一作者或共同第一作者身份在国际知名期刊Nature（2篇）、Science、Nature Medicine、Nature Communication、J Exp Med以及J Immunol上发表研究论文。多次被Nature, Nature reviews Immunology, Nature Medicine和Nature Immunology点评以及被Faculty 1000收录和推荐。总影响因子超过455，总引用超过1750次。

教育和研究经历：

2002-2006年，中国科学技术大学生命科学学院，获学士学位。

2006-2012年，上海生命科学研究院健康科学研究所，获细胞生物学博士学位。

2012-2017年，美国耶鲁大学医学院免疫学系，博士后。

2017年至今，中国科学技术大学生命科学学院，教授博导。

获奖经历：

2006年郭沫若奖学金

2011年中科院院长优秀奖

2011年强生亚洲优秀研究生论文奖

2012年中科院院长特别奖

2012年吴瑞奖学金

2012年中科院百篇优博论文

2014年Helen-Hay Whitney-HHMI奖学金

2017年中国十大新锐科技人物

2017年MIT Technology Review 35 Innovators Under 35（MIT TR35 China）

主要论著：

[01] J Tong, G Cao, T Zhang, E Sefik, M Amezcua Vesely, J Broughton, S Zhu, H Li, B Li, Lei Chen, H Chang, B Su, R Flavell & HB Li.m6A mRNA methylation sustains Treg suppressive functions.Cell Research.doi:10.1038/cr.2018.7

[02] Zhu S*, Ding S*, Wang P, Wang G, Lei X, Palm N, Pan W, Zheng Y, Feng N, Lu J, Shan L, Abraham C, Fikrig E, Greenberg H, Flavell R. Nlrp9b recognizes and restricts rotavirus infection in intestinal epithelial cells. 2017.Nature. doi:10.1038/nature22967. (Comment in Nature, doi:10.1038/nature23090,Research highlight inCell Research,doi: 10.1038/cr.2017.93,Evaluated by Faculty of 1000 Biology,*co-first author).

[03] Li, H.*, J. Tong*,S. Zhu*, P. Batista, J.Zhao, W. Bailis, Y. Yang, G. Wang, Y. Chen, Y. Kluger, Howard Y. Chang, Zhinan Yin, Richard A. Flavell. 2017. m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway.Nature. doi:10.1038/nature23450. (*co-first author)

[04] Pan W,Zhu S, K Qu, K Meeth, J Cheng,K He,H Ma, Y Liao, X Wen, C Roden, Z Tobiasova, Z Wei, J Zhao, J Liu, J Zheng, B Guo, M Bosenberg, R Flavell, J Lu.2017.Tet2 sustains the immunosuppressive function of myeloid cells and promotes melanoma growth.Immunity. 2017, doi: 10.1016/j.immuni.2017.07.020.

[05] Yu H, Borsotti C, Schickel JN,Zhu S, Strowig T, Eynon EE, Frleta D, Gurer C, Murphy AJ, Yancopoulos GD, Meffre E, Manz MG, Flavell RA. 2016. A novel humanized mouse model with significant improvement of class- switched, antigen-specific antibody production.Blood.  doi: 10.1182/blood-2016-04-709584.

[06] H Yu, N Gagliani, H Ishigame, S Huber,S Zhu, EEsplugues, K Herold, L Wen, R Flavell.2017.Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development.Proceedings of the National Academy of Sciences,doi: 10.1073/pnas.1705599114

[07] Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM,Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA. 2016. The DNA Sensing Aim2 Inflammasome Controls Radiation Induced Cell death and Tissue Injury.Science. 2016 Nov 11;354(6313):765-768.

[08] Shu Zhu, Geng Wang, Xuqiu Lei, Richard A. Flavell. 2016. Mex3B, a coreceptor to present dsRNA to TLR3.Cell Research. 26(4):391-2. doi: 10.1038/cr.2016.29.

[09] Cheng J, Roden CA, Pan W,Zhu S, Baccei A, Pan X, Jiang T, Kluger Y, Weissman SM, Guo S, Flavell RA, Ding Y, Lu J. 2016. A Molecular Chipper Technology for CRISPR sgRNA Library Generation and Functional Mapping of Noncoding Regions.Nature Communication. 7:11178. doi: 10.1038/ncomms11178.

[10] Wang P*,Zhu S*, Yang L, Cui S, Pan W, JacksonCelR, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R#, Fikrig E#. 2015. Nlrp6 regulates intestinal antiviral innate immunity.Science. 10.1126/science.aab3145. (Comment in Science Signaling (2015), *co-first author, #co-corresponding author)

[11] Pan W*,Zhu S*, Dai D, Liu Z, Li D, Li B, Gagliani N, Zheng Y,.. Qian Y, Chen Y, Fang J, Herbst R, Richman L, Jallal B, Harley J, Flavell R, Yao Y and Shen N. 2015. MiR-125a targets effector programs to stabilize Treg mediated immune homeostasis and controls autoimmunity.Nature Communication. DOI: 10.1038/ncomms8096. (*co-first author)

[12] Song X, Dai D, He X,Zhu S, Yao Y, Gao H, Wang J, Qu F, Qiu J, Wang H, Li X, Shen N, Qian Y.2015.Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage.Immunity. doi:10.1016/j.immuni.2015.06.024

[13] W Pan,S Zhu, D Dai, J Harley, N Shen. 2015. T celltransfer Model of Colitis.Bio-protocol.10.21769/BioProtoc.1862

[14] Zhu S, Li HB, Flavell RA. 2014. Resemble and Inhibit: when RLR meets TGF-b.Molecular Cell. Dec 18;56(6):719-20. doi:10.1016/j.molcel.2014.12.010

[15] Zhu S, Jackson R, Flavell RA. 2014. The lock-washer: a reconciliation of the RIG-I activation models.Cell Research.10.1038/cr.2014.5

[16] Marcel R. de Zoete*, Noah W. Palm*,Shu Zhu*, Richard A. Flavell. 2014. Inflammasomes.Cold Spring Haber Perspectives in Biology. Oct 16;6(12):a016287. doi: 10.1101/cshperspect.a016287 (*co-first author)

[17] Song X, Gao H, Lin Y, Yao Y,Zhu S, Wang J, Liu Y, Yao X, Meng G, Shen N, Shi Y, Iwakura Y, Qian Y. 2014. Alterations in the Microbiota Drive Interleukin-17C Production from Intestinal Epithelial Cells to Promote Tumorigenesis.Immunity. 40 (1), 140-152

[18] W Pan,S Zhu, D Dai, J Harley, N Shen. 2014.Mir-125a Is Critical Regulator for Controlling Autoimmunity in Multiple Autoimmune Diseases through Stabilizing Treg Mediated Immune Homeostasis.Arthritis & Rheumatology

66():S1245, OCT 2014

[19] Zhu S*, Pan W, Qian Y*. 2013. MicroRNA in immunity and autoimmunity.J Mol Med. Sep;91(9):1039-50. doi: 10.1007/s00109-013-1043-z. (*co-corresponding author; Invited review)

[20]Cao J,Zhu S, Zhou W, Li J, Liu C, Xuan H, Yan J, Zheng L, Zhou L, Yu J, Chen G, Huang Y, Yu Z, Feng L. 2013. PLZF Mediates the PTEN/AKT/FOXO3a Signaling in Suppression of Prostate Tumorigenesis.PLoS One. 8 (12), e77922

[21] Zhu, S.*, W. Pan*, X. Song, Y. Liu, Y. Tang, H. Wang, W. Liu, Y. Shi, D. He, J.B. Harley, N. Shen and Y. Qian. 2012. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α.Nature Medicine. 18: 1077-1086. DOI 10.1038/nm.2815.(Comment in Nature Reviews Immunology (2012)  474-475; Comment in Nature Medicine (2012) 18, 1009–1010; Evaluated by Faculty of 1000 Biology. *co-first author).

[22] Zhu, S. & Qian, Y. 2012. IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential.Clin Sci (Lond) 122, 487-511. (Invited review)

[23] Yao Y., Y. Wang, F. Chen, Y. Huang,S. Zhu, Q. Leng, H. Wang, Y. Shi, Y. Qian. 2012. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogen.Cell Research. 04/2012;

[24] Qu F, Gao H,Zhu S, Shi P, Zhang Y, Liu Y, Jallal B, Yao Y, Shi Y, Qian Y. 2012. TRAF6-Dependent Act1 Phosphorylation by the I kappa B Kinase-Related Kinases Suppresses Interleukin-17-Induced NF-kappa B Activation.Mol Cell Biol 32: 3925-3937.

[25] Song, X.,S. Zhu, P. Shi, Y. Liu, Y. Shi, S.D. Levin, and Y. Qian. 2011. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens.Nature Immunology. 12:1151-8.

[26] Shi, P.,S. Zhu, Y. Lin, Y. Liu, Z. Chen, Y. Shi, and Y. Qian. 2011. Persistent stimulation with interleukin-17 desensitizes cells through SCFbeta-TrCP-mediated degradation of Act1.Science Signaling. 4:ra73.

[27] Shi P,Zhu S and Y Qian. 2011. IL-17 mediated signaling and function.Chin J Cell Bio. 2011, 33(4): 345-357. (Invited review)

[28] Zhu, S., W. Pan, P. Shi, H. Gao, F. Zhao, X. Song, Y. Liu, L. Zhao, X. Li, Y. Shi, and Y. Qian. 2010. Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling.J Exp Med. 207:2647-2662. (Research highlight in Nature Medicine (2011) 17:52; Research highlight in Nature Immunology (2011) 12:19; Evaluated by Faculty of 1000 Biology).

[29] Pan, W*,S. Zhu*, M. Yuan, H. Cui, L. Wang, X. Luo, J. Li, H. Zhou, Y. Tang, and N. Shen. 2010. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1.J Immunol. 184:6773-6781.(*co-first author; 331 citations)

[30] Yu, Z., P. Ji, J. Cao,S. Zhu, Y. Li, L. Zheng, X. Chen, and L. Feng. 2009. Dazl promotes germ cell differentiation from embryonic stem cells.J Mol Cell Biol. 1:93-103.